Bioactive furanocoumarin derivatives from Ficus pumila (Moraceae. | Juan, E. A., Rideout, J. A., Ragasa, C. Y.

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Title: Bioactive furanocoumarin derivatives from Ficus pumila (Moraceae.
Personal Authors: Juan, E. A., Rideout, J. A., Ragasa, C. Y.
Author Affiliation: De La Salle Univ., Department of Chemistry, 2401 Taft Av, 1004 Manila, Philippines.
Editors: No editors
Document Title: Philippine Journal of Science

Abstract:

A report on the isolation, structure elucidation and bio-assay of 2 compounds, bergapten and oxypeucedanin hydrate, from the chloroform extract of Ficus pumila is presented. The compounds were tested for antimicrobial activity against 6 micro-organisms by the agar well method. Bergapten was found to inhibit the growth of Staphylococcus aureus, Escherichia coli and Salmonella typhi, but was inactive against Trichophyton mentagrophytes, Mycobacterium pleie and Candida albicans. Oxypeucedanin hydrate inhibited the growth of Salmonella typhi, but was found inactive against the other 5 micro-organisms. Both compounds were also tested for antimutagenic activity using the micronucleus test. Results of the study indicated that bergapten reduced the number of micronucleated polychromatic erythrocytes (MPCE) induced by mitomycin C by 44%, while oxypeucedanin hydrate reduced MPCE by 74%. From authors' summary. KEYWORDS: TROPAG | Ficus | drug plants | Ficus | antimicrobials | antibiotics | medicinal properties | ornamental plants.

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