Chromosome and DNA damage analysis in individuals occupationally exposed to pesticides with relation to genetic polymorphism for CYP 1A1 gene in Ecuador. | Paz-y-Miño, C., Arévalo, M., Sanchez, M. E., Leone, P. E. | Mutation Research, Genetic Toxicology and Environmental Mutagenesis

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Title: Chromosome and DNA damage analysis in individuals occupationally exposed to pesticides with relation to genetic polymorphism for CYP 1A1 gene in Ecuador.
Personal Authors: Paz-y-Miño, C., Arévalo, M., Sanchez, M. E., Leone, P. E.
Author Affiliation: Laboratorio de Genética Molecular, y Citogenética Humana, Escuela de Biología, Pontificia Universidad Católica del Ecuador, Quito, Ecuador.
Editors: No editors
Document Title: Mutation Research, Genetic Toxicology and Environmental Mutagenesis

Abstract:

DNA damage was measured by using the alkaline comet assay and the chromosomal aberration (CA) test using peripheral blood samples from 45 pesticide sprayers from Cayambe, Ecuador. From a total of approximately 200 nuclei scored for each donor with the comet assay, a highly significant increase in DNA migration was observed when compared with a similar unexposed control population. Additionally, in the CA test, the exposed individuals were found to be significantly different when compared to the control population. Polymorphisms for the CYP 1A1 (Msp I and Ile/Val) in exposed individuals were analysed by PCR-RFLP and allele-specific PCR techniques. No association was found between the polymorphisms and higher levels of DNA damage as assessed by the comet assay.

Publisher: Elsevier Science B.V.

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