Genetic environment of CTX-M-2 in Klebsiella pneumoniae isolates from hospitalized patients in Uruguay. | Vignoli, R., Cordeiro, N., Seija, V., Schelotto, F., Radice, M., Ayala, J., Power, P., Gutkind, G. | Revista Argentina de Microbiología

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Title: Genetic environment of CTX-M-2 in Klebsiella pneumoniae isolates from hospitalized patients in Uruguay.
Personal Authors: Vignoli, R., Cordeiro, N., Seija, V., Schelotto, F., Radice, M., Ayala, J., Power, P., Gutkind, G.
Author Affiliation: Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina, Universidad de la República, Alfredo Navarro 3051, Montevideo, Uruguay.
Editors: No editors
Document Title: Revista Argentina de Microbiología

Abstract:

Two Klebsiella pneumoniae clinical strains (K96005 and K13) producing CTX-M-2 were isolated from hospitalized patients in Uruguay during 1996 and 2003 and studied. The genomic surroundings of bla_CTX-M-2 were characterized by PCR mapping and DNA sequencing. The results showed that bla_CTX-M-2 was included in a complex class-1 integron (InK13), associated with an orf513 in both isolates. The genetic array of the integron, aac(6′)-lb, bla_OXA-2, orfD (gene cassette region), associated with an orf513-bla_CTX-M-2, seemed to be widely disseminated over the Río de la Plata region.

Publisher: Asociación Argentina de Microbiología

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